Building for Transformative Medicine, 60 Fenwood Road, Boston MA

Yongju Lee, PhD, Genentech – “Contextual representation of pathology, immune repertoire by transformer and graph neural network, and transcriptomic contextual embedding via single-cell foundation model”

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The graph neural network (GNN) and transformer model are two renowned neural network architectures for obtaining contextual embeddings from biomedical data. However, each model has a trade-off in terms of the required dataset for training and representation power of the model. As examples, I will discuss the TEA-graph which employs GNN to define the contextual […]

Weiruo Zhang, PhD, Stanford University-“Integrative spatial-omics analysis of cellular architecture mediating lymph node metastasis in head and neck cancer”

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Spatial biology is a new frontier that has become accessible through advances in spatial profiling technologies, such as multiplexed in situ imaging spatial proteomics, which can provide single-cell resolution up to 60 markers. In this talk, I will introduce a computational analysis pipeline that performs integrative analysis of spatial proteomics and single-cell RNA sequencing to […]