Cheng-Zhong Zhang, PhD


Assistant Professor of Pathology
Harvard Medical School

Assistant Professor of Data Science
Dana-Farber Cancer Institute

Assistant Professor
Division of Computational Pathology, Brigham and Women’s Hospital


PhD, California Institute of Technology


Research in the Zhang laboratory focuses on three broad questions about cancer genomic rearrangements:

  1. What types of rearrangements are present in normal and cancer cells?
  2. How and when do these alterations arise during tumorigenesis?
  3. How do rearrangements contribute to tumorigenesis and what dependencies are created by genome instability?

We address these questions by crafting computational methods for the precise resolution of genomic rearrangements and applying these methods to both primary tissue specimens and experimental cell line models to generate biological insights. We collaborative extensively with clinicians, cancer biologists, and cell biologists.


Cheng-Zhong (CZ) Zhang obtained a Ph.D. in Chemical Engineering with a minor in Physics from Caltech. He completed a postdoctoral fellowship on single-molecule biophysics (PI: Timothy Springer) and then received training in computational genomics and cancer biology under the supervision of Matthew Meyerson and David Pellman.