Speaker: Bokai Zhu, PhD
Affiliation: Ragon Institute of MGH, Harvard and MIT, Broad Institute, MIT
Position: Postdoctoral Research Fellow
Host: Muhammad Shaban, PhD – Mahmood Lab
Date: Monday September 23, 2024
Time: 1:00-2:00PM ET
In person: Duncan Reid Conference Room (directions below)
Zoom: https://partners.zoom.us/j/82163676866
Meeting ID: 821 6367 6866
Abstract: Advancements in single-cell and spatial-omics technologies have created a need for integrating datasets across modalities with limited and weakly correlated features, such as those between spatial proteomics and transcriptomics. Existing tools, usually designed for strongly linked data, often fail in these scenarios. Recently, we have developed a series of methods (Mario and MaxFuse), that improves integration by refining weak correlations between modalities through an iterative smoothing and co-embedding process, and achieves single-cell level matching across these weakly linked modalities, enabling in-depth understanding of tissue micro-environments.
Research Links: https://bokaizhu.github.io/
Bokai Zhu is currently a postdoctoral researcher supervised by Prof. Alex Shalek at the Ragon Institute at MGH, MIT, and Harvard. Prior to that, Dr. Zhu obtained his PhD in Microbiology and Immunology from Stanford University, under the supervision of Prof. Garry Nolan. He received a bachelor’s degree in Biology from Cornell University and Zhejiang University. Dr. Zhu’s doctoral research focused on: 1) Experimental assay development for multiplex imaging platforms; 2) Computational algorithm development for single-cell multi-omic integrations; 3)Application of the above tools in various biological systems.
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Directions: Duncan Reid Conference Room is located in ASB-1 2nd Floor
When entering the hospital from the main entrance, 75 Francis Street
– Follow the lobby around to the right and take large staircase in front of you to the 2nd floor, then take a left at top of stairs
– When on the main Pike, take the next right at corridor (across from children’s hospital bridge), and a right past the (K) elevators, door straight ahead(Rm #A1020)